Conference Proceedings
Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma
MA Rodriguez-Bigas, HFA Vasen, HT Lynch, P Watson, T Myrhøj, HJ Järvinen, JP Mecklin, F Macrae, DJB St. John, L Bertario, P Fidalgo, L Madlensky, P Rozen
Cancer | WILEY-LISS | Published : 1998
Abstract
BACKGROUND. Small bowel carcinoma is uncommon. However, hereditary nonpolyposis colorectal carcinoma (HNPCC) patients are at increased risk of small bowel carcinoma. The purpose of this study was to characterize small bowel tumors in HNPCC patients. METHODS. A questionnaire was mailed to the members of International Collaborative Group on HNPCC (ICG-HNPCC) requesting clinicopathologic data in their registries on HNPCC patients with small bowel carcinoma. Survival was estimated utilizing the Kaplan-Meier method. RESULTS. Forty-two individuals from 40 HNPCC families developed 42 primary and 7 metachronous small bowel tumors. There were 46 adenocarcinomas and 3 carcinoid tumors. The median age ..
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