Journal article

ELECTRICAL-STIMULATION OF THE AUDITORY-NERVE IN DEAF KITTENS - EFFECTS ON COCHLEAR NUCLEUS MORPHOLOGY

JI MATSUSHIMA, RK SHEPHERD, HL SELDON, SA XU, GM CLARK

HEARING RESEARCH | ELSEVIER SCIENCE BV | Published : 1991

Abstract

The present study examines the effects of long-term electrical stimulation of the auditory nerve on the morphology of neurons in the cochlear nucleus in young, sensorineural deaf animals. Kittens, systemically deafened using kanamycin and ethacrynic acid, received bilateral cochlear implants and were stimulated unilaterally for periods of up to four months. After sacrifice, cross-sectional areas of neuron somata were measured with an image-analysis system and compared using nonparametric statistics. The areas of cell somata within the anteroventral cochlear nucleus (AVCN) on the stimulated side were significantly larger than those of corresponding somata on the control, unstimulated side (P ..

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