Journal article

[A rat model for cochlear implant research].

Wei Lu, Jin Xu, RK Shepherd

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | Published : 2008


OBJECTIVE: To introduce a rat model for use in cochlear implant related research. METHOD: Five deafened Hooded-Wistar rats were implanted with a scala tympani electrode array using a new surgical method. Electrically evoked brainstem responses (EABRs) using bipolar stimulation were recorded and cochlear history was assessed. RESULT: Electrically evoked brainstem responses with normal configuration confirmed the functional status of the cochlear implantation. There was no evidence of severe insertion-induced damage of intra-cochlear structure. CONCLUSION: The surgical method established in the rat model is a safe and effective procedure for acute or chronic cochlear implantation.

University of Melbourne Researchers