Journal article
[A rat model for cochlear implant research].
W Lu, J Xu, RK Shepherd
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Journal of Clinical Otorhinolaryngology Head and Neck Surgery | Published : 2008
Abstract
To introduce a rat model for use in cochlear implant related research. Five deafened Hooded-Wistar rats were implanted with a scala tympani electrode array using a new surgical method. Electrically evoked brainstem responses (EABRs) using bipolar stimulation were recorded and cochlear history was assessed. Electrically evoked brainstem responses with normal configuration confirmed the functional status of the cochlear implantation. There was no evidence of severe insertion-induced damage of intra-cochlear structure. The surgical method established in the rat model is a safe and effective procedure for acute or chronic cochlear implantation.
Grants
Awarded by NIDCD NIH HHS