Journal article

Response of inferior colliculus neurons to electrical stimulation of the auditory nerve in neonatally deafened cats

RK Shepherd, JH Baxi, NA Hardie

JOURNAL OF NEUROPHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 1999

Abstract

Response properties of neurons in the inferior colliculus (IC) were examined in control and profoundly deafened animals to electrical stimulation of the auditory nerve. Seven adult cats were used: two controls; four neonatally deafened (2 bilaterally, 2 unilaterally); and one long-term bilaterally deaf cat. All control cochleae were deafened immediately before recording to avoid electrophonic activation of hair cells. Histological analysis of neonatally deafened cochleae showed no evidence of hair cells and a moderate to severe spiral ganglion cell loss, whereas the long-term deaf animal had only 1-2% ganglion cell survival. Under barbiturate anesthesia, scala tympani electrodes were implant..

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University of Melbourne Researchers