Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
John Burn, Anne-Marie Gerdes, Finlay Macrae, Jukka-Pekka Mecklin, Gabriela Moeslein, Sylviane Olschwang, Diane Eccles, D Gareth Evans, Eamonn R Maher, Lucio Bertario, Marie-Luise Bisgaard, Malcolm G Dunlop, Judy WC Ho, Shirley V Hodgson, Annika Lindblom, Jan Lubinski, Patrick J Morrison, Victoria Murday, Raj Ramesar, Lucy Side Show all
The Lancet | ELSEVIER SCIENCE INC | Published : 2011
Awarded by Cancer Research UK
Awarded by Medical Research Council
Awarded by National Institute for Health Research
European Union; Cancer Research UK; Bayer Corporation; National Starch and Chemical Co; UK Medical Research Council; Newcastle Hospitals trustees; Cancer Council of Victoria Australia; THRIPP South Africa; The Finnish Cancer Foundation; SIAK Switzerland; Bayer Pharma.The CAPP2 study is an academic collaboration. Funding was initially provided by a European Union award supplemented by Programme funding in Newcastle and Leeds from Cancer Research UK (C588/A10589). Following completion of design and choice of interventions, Bayer Corporation and National Starch and Chemical Co were approached for support. Both provided free intervention including the cost of packaging and made donations to Newcastle University to help cover the cost of administration and distribution. They had no influence on design, conduct, or analysis of the study. The contracts associated with their donations required that they be given sight of the results before submission with up to 90 days for evaluation. The UK Medical Research Council (MRC) approved the trial in 2002 and became the primary funder. MRC steering and data monitoring committees were established. Financial contributions were also made to local sites by the Newcastle Hospitals trustees, Cancer Council of Victoria Australia, THRIPP South Africa, The Finnish Cancer Foundation and SIAK Switzerland. When renewal requests were declined by MRC and Cancer Research UK, follow-up analysis 2009-11 was supported by a donation from Bayer Schering Pharma to Newcastle University. CAPP2 has been made possible by all the participants who agreed to be randomised and take daily treatments for up to 4 years. Special mention must also be given to Pascale Ives (Melbourne, Australia) and Su Werner (Dusseldorf, Germany) for their exceptional recruitment achievements and to Pam Chapman, the project manager in the early stages of the CAPP2 study. Other core staff were Paul Adamson, Olive Armstrong, Julie Coaker, Jonathan Coxhead, Joanne Gascoyne, John Gilroy, Louise Lynagh, Lynn Reed, and Rachel Toes. Recruitment depended on a large number of colleagues around the world. Clinical collaborators not listed as authors are: Jan Ball, Lauren Baxter, Alex Boussioutas, Nicola Bradshaw, Carole Brewer, Mary Broughton, Barbara Bulman, Monica Castiglione, Sue Clark, Rowena Ching, Carol Chu, Susanne Cina, Jackie Cook, Carole Cummings, Rhodri Davies, Tadeusz Debniak, Celine de Moncuit, Sarah Drummond, Tony Ellis, Paulo Fidalgo, Steve Gallinger, Sheila Goff, Paul A Goldberg, Selina Goodman, Chris Harocopos, Pierre Hutter, Lisa Jeffers, Sheila Jordan, Pip Killick, Christian Krauss, Jorgen Kristensen, Caroline Langman, Julio Leite, Annelie Liljegren, Cristina Oliani, Christopher Marks, Veronique Membrez-Antonioli, Julie Miller, Tony Miles, Pedro Perez Segura, Gabriella Pichert, Elize Pietersen, Giovanni Rossi, Paola Sala, Julian Sampson, Beverly Schmocker, Joan Shaw, Allan Spigelman, Alfonso Tempesta, Mary Velthuizen, and Ian Walpole. We are also indebted to the trial steering committee (David Kerr [Chair], Sarah Perkins [MRC], Jack Cuzick, Lynn Faulds Wood, Robert Steele) and the data monitoring committee (Doug Altman [Chair], Chris Paraskeva, Wendy Atkin, Mark Hull). We are grateful to the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) for its support, since its formation in 2003, in sustaining the CAPP consortium.