Journal article

Development of receptoral responses in pigmented and albino guinea-pigs (Cavia porcellus)

BV Bui, AJ Vingrys

DOCUMENTA OPHTHALMOLOGICA | KLUWER ACADEMIC PUBL | Published : 1999

Abstract

We describe the postnatal development of the electroretinogram (ERG) receptoral response in the guinea pig. In addition, the time course and nature of maturation was compared between albino and pigmented strains to consider the role that melanogenesis might have in this process. Electroretinograms were collected on groups of albino and pigmented animals from postnatal day (PD) PD1 to PD60. A-wave amplitudes and implicit times were extracted from filtered data (0-75 Hz). Receptoral components were modelled using the delayed gaussian model of Hood and Birch [1] fitted as an ensemble to the raw data. Guinea pigs show saturated amplitudes (RmP3) that are 50% of adult values at birth, these matur..

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