Journal article

Perfusion computed tomography to assist decision making for stroke thrombolysis

Andrew Bivard, Christopher Levi, Venkatesh Krishnamurthy, Patrick McElduff, Ferdi Miteff, Neil J Spratt, Grant Bateman, Geoffrey Donnan, Stephen Davis, Mark Parsons

BRAIN | OXFORD UNIV PRESS | Published : 2015


The use of perfusion imaging to guide selection of patients for stroke thrombolysis remains controversial because of lack of supportive phase three clinical trial evidence. We aimed to measure the outcomes for patients treated with intravenous recombinant tissue plasminogen activator (rtPA) at a comprehensive stroke care facility where perfusion computed tomography was routinely used for thrombolysis eligibility decision assistance. Our overall hypothesis was that patients with 'target' mismatch on perfusion computed tomography would have improved outcomes with rtPA. This was a prospective cohort study of consecutive ischaemic stroke patients who fulfilled standard clinical/non-contrast comp..

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