The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia
Cedric S Tremblay, David J Curtis
CURRENT OPINION IN HEMATOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
PURPOSE OF REVIEW: Recent genome sequencing studies have identified a broad spectrum of gene mutations in T-cell acute lymphoblastic leukemia (T-ALL). The purpose of this review is to outline the latest advances in our understanding of how these mutations contribute to the formation of T-ALL. RECENT FINDINGS: Aberrant expression of transcription factors that control hematopoiesis can induce an aberrant stem cell-like program in T-cell progenitors, allowing the emergence of an ancestral or preleukemic stem cell (pre-LSC). In contrast, gain-of-function mutations of genes involved in signaling pathways regulating T-cell development, such as NOTCH1, interleukin-7, KIT and FLT3, are insufficient ..View full abstract
Research work by C.S.T is supported by a grant-in-aid by the Leukaemia Foundation of Australia, and D.J.C. is a Senior Medical Research Fellow of the Sylvia & Charles Viertel Charitable Foundation and receiving project grants from the National Health and Medical Research Council of Australia (NHMRC).