Journal article

The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia

Cedric S Tremblay, David J Curtis

CURRENT OPINION IN HEMATOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

PURPOSE OF REVIEW: Recent genome sequencing studies have identified a broad spectrum of gene mutations in T-cell acute lymphoblastic leukemia (T-ALL). The purpose of this review is to outline the latest advances in our understanding of how these mutations contribute to the formation of T-ALL. RECENT FINDINGS: Aberrant expression of transcription factors that control hematopoiesis can induce an aberrant stem cell-like program in T-cell progenitors, allowing the emergence of an ancestral or preleukemic stem cell (pre-LSC). In contrast, gain-of-function mutations of genes involved in signaling pathways regulating T-cell development, such as NOTCH1, interleukin-7, KIT and FLT3, are insufficient ..

View full abstract