Journal article

Inertial imaging with nanomechanical systems

M Selim Hanay, Scott I Kelber, Cathal D O'Connell, Paul Mulvaney, John E Sader, Michael L Roukes

NATURE NANOTECHNOLOGY | NATURE PUBLISHING GROUP | Published : 2015

Abstract

Mass sensing with nanoelectromechanical systems has advanced significantly during the last decade. With nanoelectromechanical systems sensors it is now possible to carry out ultrasensitive detection of gaseous analytes, to achieve atomic-scale mass resolution and to perform mass spectrometry on single proteins. Here, we demonstrate that the spatial distribution of mass within an individual analyte can be imaged--in real time and at the molecular scale--when it adsorbs onto a nanomechanical resonator. Each single-molecule adsorption event induces discrete, time-correlated perturbations to all modal frequencies of the device. We show that by continuously monitoring a multiplicity of vibrationa..

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Grants

Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

The authors acknowledge support from an NIH Director's Pioneer award (to M.L.R.), a Caltech Kavli Nanoscience Institute Distinguished Visiting Professorship (to J.E.S.), the Fondation pour la Recherche et l'EnseignementSuperieur, Paris (FRES; to M.L.R.), and the Australian Research Council grants scheme (P.M. and J.E.S.).