Journal article

Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy

Selwyn M Prea, Elsa C Chan, Gregory J Dusting, Algis J Vingrys, Bang V Bui, Guei-Sheung Liu



Age-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. The advanced neovascular (or "wet") form of the disease is responsible for severe and aggressive loss of central vision. Current treatments aim to seal off leaky blood vessels via laser therapy or to suppress vessel leakage and neovascular growth through intraocular injections of antibodies that target vascular endothelial growth factor (VEGF). However, the long-term success of anti-VEGF therapy can be hampered by limitations such as low or variable efficacy, high frequency of administration (usually monthly), potentially serious sid..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This work was supported by project grants from the National Health and Medical Research Council of Australia (NHMRC #1061912) and the Ophthalmic Research Institute of Australia. Gregory J. Dusting receives a Principal Research Fellowship from NHMRC. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.