Journal article
Transcription and Pathway Analysis of the Superior Temporal Cortex and Anterior Prefrontal Cortex in Schizophrenia
Michael R Barnes, Julie Huxley-Jones, Peter R Maycox, Mark Lennon, Amy Thornber, Fiona Kelly, Stewart Bates, Adam Taylor, Juliet Reid, Neil Jones, Joern Schroeder, Carol A Scorer, Ceri Davies, Jim J Hagan, James NC Kew, Claire Angelinetta, Tariq Akbar, Steven Hirsch, Ann M Mortimer, Thomas RE Barnes Show all
JOURNAL OF NEUROSCIENCE RESEARCH | WILEY-BLACKWELL | Published : 2011
DOI: 10.1002/jnr.22647
Abstract
The molecular basis of schizophrenia is poorly understood; however, different brain regions are believed to play distinct roles in disease symptomology. We have studied gene expression in the superior temporal cortex (Brodmann area 22; BA22), which may play a role in positive pathophysiology, and compared our results with data from the anterior prefrontal cortex (BA10), which shows evidence for a role in negative symptoms. Genome-wide mRNA expression was determined in the BA22 region in 23 schizophrenics and 19 controls and compared with a BA10 data set from the same subjects. After adjustments for confounding sources of variation, we carried out GeneGO pathway enrichment analysis in each re..
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Funding Acknowledgements
Contract grant sponsor: GlaxoSmithKline.