On-lattice agent-based simulation of populations of cells within the open-source Chaste framework
Grazziela P Figueredo, Tanvi V Joshi, James M Osborne, Helen M Byrne, Markus R Owen
Interface Focus | ROYAL SOC | Published : 2013
Over the years, agent-based models have been developed that combine cell division and reinforced random walks of cells on a regular lattice, reaction-diffusion equations for nutrients and growth factors; and ordinary differential equations for the subcellular networks regulating the cell cycle. When linked to a vascular layer, this multiple scale model framework has been applied to tumour growth and therapy. Here, we report on the creation of an agent-based multi-scale environment amalgamating the characteristics of these models within a Virtual Physiological Human (VPH) Exemplar Project. This project enables reuse, integration, expansion and sharing of the model and relevant data. The agent..View full abstract
Awarded by European Community
Awarded by King Abdullah University of Science and Technology (KAUST)
The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under the project 'Virtual Physiological Human Network of Excellence', grant agreement no. 223920. This work was also supported in part by award no. KUK-013-04, made by the King Abdullah University of Science and Technology (KAUST).