Journal article

Modelling the role of the basement membrane beneath a growing epithelial monolayer

Sara-Jane Dunn, Alexander G Fletcher, S Jonathan Chapman, David J Gavaghan, James M Osborne

Journal of Theoretical Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2012

Abstract

The role of the basement membrane is vital in maintaining the integrity and structure of an epithelial layer, acting as both a mechanical support and forming the physical interface between epithelial cells and the surrounding connective tissue. The function of this membrane is explored here in the context of a growing epithelial monolayer, defined such that the epithelial cells divide and migrate along a deformable substrate. A discrete, off-lattice cell-centre modelling approach is undertaken, which permits definition of a basement membrane component, separating the epithelial cells from the tissue stroma whilst responding to forces from both that arise due to cell division, migration and a..

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University of Melbourne Researchers

Grants

Awarded by Life Sciences Interface Doctoral Training Centre


Awarded by OCISB


Awarded by Engineering and Physical Sciences Research Council


Funding Acknowledgements

S.J.D. is supported by an EPSRC-funded Life Sciences Interface Doctoral Training Centre studentship (Grant reference EP/E501605/1). A.G.F., D.J.G. and J.M.O. are funded through the OCISB project (BB/D020190/1).