Journal article

Computational Models Reveal a Passive Mechanism for Cell Migration in the Crypt

Sara-Jane Dunn, Inke S Naethke, James M Osborne



Cell migration in the intestinal crypt is essential for the regular renewal of the epithelium, and the continued upward movement of cells is a key characteristic of healthy crypt dynamics. However, the driving force behind this migration is unknown. Possibilities include mitotic pressure, active movement driven by motility cues, or negative pressure arising from cell loss at the crypt collar. It is possible that a combination of factors together coordinate migration. Here, three different computational models are used to provide insight into the mechanisms that underpin cell movement in the crypt, by examining the consequence of eliminating cell division on cell movement. Computational simul..

View full abstract

University of Melbourne Researchers


Awarded by Cancer Research UK

Awarded by Systems Approaches to Biomedical Science Industrial Doctorate Centres

Funding Acknowledgements

This work was supported by funding from Cancer Research UK to ISN, grant number C430/A11243. JMO is supported by the EPSRC through the Life Sciences Interface, the Systems Biology, and the Systems Approaches to Biomedical Science Industrial Doctorate Centres (EP/E501605/1, EP/G50029/1 and EP/G037280/1 respectively) and Microsoft Research through the 2020 Science Project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.