Journal article

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

Scott N Mueller, Mehrdad Matloubian, Daniel M Clemens, Arlene H Sharpe, Gordon J Freeman, Shivaprakash Gangappa, Christian P Larsen, Rafi Ahmed

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2007

Abstract

Many chronic viral infections are marked by pathogen persistence and a generalized immunosuppression. The exact mechanisms by which this occurs are still unknown. Using a mouse model of persistent lymphocytic choriomeningitis virus (LCMV) infection, we demonstrate viral targeting of fibroblastic reticular cells (FRC) in the lymphoid organs. The FRC stromal networks are critical for proper lymphoid architecture and function. High numbers of FRC were infected by LCMV clone 13, which causes a chronic infection, whereas few were infected by the acute strain, LCMV Armstrong. The function of the FRC conduit network was altered after clone 13 infection by the action of CD8(+) T cells. Importantly, ..

View full abstract

University of Melbourne Researchers