Extracellular Guanosine 3′,5′-Cyclic Monophosphate and Disodium Cromoglycate Share a Similar Spectrum of Activity in the Inhibition of Histamine Release from Isolated Mast Cells and Basophils

Abstract

In comparison to adenosine 3′,5′-cyclic monophosphate (cAMP), surprisingly little is known regarding the role of guanosine 3′,5′-cyclic monophosphate (cGMP) in the functional modulation of mast cells and basophils. In the present study, the ability of cGMP, cAMP, and a range of related compounds, to inhibit immunologically induced histamine release from these cells was investigated and compared to the anti-asthmatic drug disodium cromoglycate (DSCG). Exogenously applied cGMP produced a potent inhibition of histamine release from rat peritoneal mast cells, but cAMP had a negligible effect. The attenuation noted with cGMP was markedly reduced if cells were pretreated with the nucleotide before..