Journal article

CHARACTERIZATION OF H2-INFLUENZA VIRUS HEMAGGLUTININ WITH MONOCLONAL-ANTIBODIES - INFLUENCE OF RECEPTOR SPECIFICITY

A YAMADA, LE BROWN, RG WEBSTER

VIROLOGY | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1984

Abstract

Antigenic analysis of human and avian H2 influenza viruses were done with monoclonal antibodies to the HA molecules in hemagglutination inhibition (HI) assays. These studies revealed that the receptor-binding specificity of the hemagglutinin can markedly influence the antigenic analysis obtained with monoclonal antibodies in HI tests. Influenza viruses that are sensitive or resistant to inhibition by horse serum inhibitors showed marked differences in their reactivity with monoclonal antibodies to the hemagglutinin. This was apparent with the A/RI/5+/57 and A/RI/5-/57 strains of H2N2 viruses isolated by Choppin and Tamm (1960a), half of the panel of different monoclonal antibodies failed to ..

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University of Melbourne Researchers