Journal article

Manipulation of the helper T cell response to influence antigenic competition occurring with a multivalent vaccine

JD Hunt, LE Brown, PR Wood, DJ Stewart, DC Jackson

IMMUNOLOGY AND CELL BIOLOGY | BLACKWELL SCIENCE | Published : 1996

Abstract

The reduction in antibody observed following inoculation with multiple heterologous Dichelobacter nodosus pili antigens is thought to be due to competition between antigen-specific B cells for a limited amount of T cell help. We demonstrate here that this competition is not further influenced by the expansion of cross-reactive antibody secreting cells at the expense of serogroup specific antibody secreting cells. The T cell determinants of pili recognized by sheep and BALB/c mice have been defined using 15 residue peptides. These T cell determinants include cross-reactive determinants in the conserved amino terminal region of the antigen. Here we investigate the effect of expanding the pili-..

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