Conserved determinants for CD4 T cells within the light chain of the H3 hemagglutinin molecule of influenza virus.
DC Jackson, HE Drummer, LE Brown
Virology | Published : 1994
Helper T-cell clones were isolated from BALB/c mice that had been inoculated with purified light chain (HA2) from H3 subtype influenza virus hemagglutinin (HA). The clones were divided into two distinct groups based on their ability to proliferate in response to bromelain-derived HA (BHA) and the light chain derived from it (BHA2), both of which lack the C-terminal 46 amino acid residues of the HA2 chain. The first group contained two I-Ad restricted clones that proliferated in response to BHA and BHA2 and were found to recognize the determinant 96AELLVALEN104. The remaining seven clones were I-Ed restricted, required intact HA2 for proliferation, and responded to synthetic peptides containi..View full abstract