Journal article

MODULATION OF CD4 T-CELL RECOGNITION OF INFLUENZA HEMAGGLUTININ BY CARBOHYDRATE SIDE-CHAINS LOCATED OUTSIDE A T-CELL DETERMINANT

HE DRUMMER, DC JACKSON, LE BROWN

VIROLOGY | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1993

Abstract

Two distinct T-cell clones raised to the H3 subtype influenza virus A/Memphis/71 fail to proliferate in response to other H3 viruses that contain the amino acid substitution Asp63-->Asn within the heavy (HA1) chain of the hemagglutinin (HA). These nonstimulatory viruses nevertheless have an intact sequence corresponding to the determinants recognized by the clones. The substitution at residue 63 results in the creation of a potential glycosylation site which occurs outside the boundaries of the T-cell determinants. A synthetic peptide encompassing the two determinants and extended to include residue Asn63 stimulated levels of proliferation of the clones similar to those obtained with a pepti..

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