Journal article

NEUTRALIZING MONOCLONAL-ANTIBODIES AGAINST 3 SEROTYPES OF PORCINE ROTAVIRUS

HS NAGESHA, LE BROWN, IH HOLMES

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 1989

Abstract

Using three serotypes (four strains) of cultivable porcine rotavirus as immunizing antigens, 10 neutralizing monoclonal antibodies were characterized. One VP4-specific monoclonal antibody directed against porcine rotavirus BEN-144 (serotype G4) neutralized human rotavirus strain ST-3 in addition to the homologous porcine virus. All nine VP7-specific monoclonal antibodies were highly specific for viruses of the same serotype as the immunizing rotavirus strain. One exception was the VP7-specific monoclonal antibody C3/1, which neutralized both serotype G3 and G5 rotaviruses. However, this monoclonal antibody did not neutralize the porcine rotavirus AT/76, also of serotype G3, nor mutants of SA..

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University of Melbourne Researchers