beta-cell regeneration and differentiation: how close are we to the 'holy grail'?
Gemma Tan, Andrew G Elefanty, Edouard G Stanley
JOURNAL OF MOLECULAR ENDOCRINOLOGY | BIOSCIENTIFICA LTD | Published : 2014
Diabetes can be managed by careful monitoring of blood glucose and timely delivery of exogenous insulin. However, even with fastidious compliance, people with diabetes can suffer from numerous complications including atherosclerosis, retinopathy, neuropathy, and kidney disease. This is because delivery of exogenous insulin coupled with glucose monitoring cannot provide the fine level of glucose control normally provided by endogenous β-cells in the context of intact islets. Moreover, a subset of people with diabetes lack awareness of hypoglycemic events; a status that can have grave consequences. Therefore, much effort has been focused on replacing lost or dysfunctional β-cells with cells de..View full abstract
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Awarded by National Institute on Minority Health and Health Disparities
This work was supported by grants from the Australian Stem Cell Centre, Stem Cells Australia, The Juvenile Diabetes Research Foundation, and the National Health and Medical Research Council of Australia (NHMRC). A G E and E G S are Senior Research Fellows of the NHMRC. This work was also supported by the Victorian Government's Operational Infrastructure Support Program.