Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase inhibitors: design, synthesis, X-ray diffraction analysis and molecular docking studies
Imtiaz Khan, Syeda Mahwish Bakht, Aliya Ibrar, Saba Abbas, Shahid Hameed, Jonathan M White, Usman Ali Rana, Sumera Zaib, Mohammad Shahid, Jamshed Iqbal
RSC ADVANCES | ROYAL SOC CHEMISTRY | Published : 2015
There is a high demand for the collection of small organic molecules (especially N-heterocycles) with diversity and complexity in the process of drug discovery. This need for privileged scaffolds in medicinal research gives an impetus for the development of nitrogen-containing compounds which are widely encountered in natural products, drugs and pharmaceutically active compounds. In this context, a diverse library of new triazolothiadiazole (4a-l) and triazolothiadiazine (5a-p) compounds was designed, synthesized and evaluated as potent and selective inhibitors of electric eel acetylcholinesterase (EeAChE) and horse serum butyrylcholinesterase (hBChE) by Ellman's method using neostigmine and..View full abstract
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Awarded by Deanship of Scientific Research at King Saud University
The authors would like to sincerely appreciate the Deanship of Scientific Research at King Saud University for its funding through the Research Group Project no RGV-VPP-345.