Journal article

Spontaneous swallowing occurs during autoresuscitation in the in situ brainstem preparation of rat

Tara G Bautista, Angelina Y Fong, Mathias Dutschmann

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | ELSEVIER | Published : 2014

Abstract

Previous studies report that upper airway reflexes are operational during autoresuscitation from respiratory arrest. We investigated swallowing/breathing interactions, measured by recording of vagal (VNA) and phrenic nerve activities (PNA), during autoresuscitation in the in situ perfused brainstem preparation of juvenile rats. During the initial surgery, respiratory arrest was induced by exsanguination and cooling. Reperfusion (i.e. re-oxygenation and re-warming) of the brainstem circuits was associated with frequent spontaneous swallowing before resumption of respiration (n=6, 'stage 1 autoresuscitation'). When recovered, the respiratory pattern was transiently apneustic-like ('stage 2 aut..

View full abstract