Journal article

Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial

Xavier Castellsague, Jorma Paavonen, Unnop Jaisamrarn, Cosette M Wheeler, S Rachel Skinner, Matti Lehtinen, Paulo Naud, Song-Nan Chow, Maria Rowena Del Rosario-Raymundo, Julio C Teixeira, Johanna Palmroth, Newton S de Carvalho, Maria Julieta V Germar, Klaus Peters, Suzanne M Garland, Anne Szarewski, Willy AJ Poppe, Barbara Romanowski, Tino F Schwarz, Wiebren AA Tjalma Show all



BACKGROUND: More information is needed about time between sexual initiation and human papillomavirus (HPV) infection and development of cervical precancer. METHODS: The objectives were to investigate the time between first sexual activity and detection of first cervical HPV infection or development of first cervical intraepithelial neoplasia (CIN), and associated factors in women from the double-blind, multinational, 4-year PATRICIA trial. PATRICIA enroled women aged 15-25 years with no more than 6 lifetime sexual partners. Women were randomized 1:1 to the HPV-16/18 AS04-adjuvanted vaccine or to control, but only women from the control arm who began sexual intercourse during the study or wit..

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