Journal article

Cortical structural abnormalities in very preterm children at 7 years of age

Yuning Zhang, Terrie E Inder, Jeffrey J Neil, Donna L Dierker, Dimitrios Alexopoulos, Peter J Anderson, David C Van Essen

NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015

Abstract

We analyzed long-lasting alterations in brain morphometry associated with preterm birth using volumetric and surface-based analyses applied to children at age 7 years. Comparison of 24 children born very preterm (VPT) to 24 healthy term-born children revealed reductions in total cortical gray matter volume, white matter volume, cortical surface area and gyrification index. Regional cortical shape abnormalities in VPT children included the following: shallower anterior superior temporal sulci, smaller relative surface area in the inferior sensori-motor cortex and posterior superior temporal cortex, larger relative surface area and a cingulate sulcus that was shorter or more interrupted in med..

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Grants

Awarded by NIH


Awarded by National Medical and Health Research Council of Australia Project Grants


Awarded by Senior Research Fellowship


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

We thank Drs. Lex Doyle and Deanne Thompson for their important roles in the VIBeS longitudinal study. This work was supported by research grants from the NIH (R01 HD05709801, R01 MH60974, and P30 HD062171), the Doris Duke Foundation Distinguished Clinical Scientist Award, the National Medical and Health Research Council of Australia Project Grants (237117 & 491209), Senior Research Fellowship (628371) (to P. A.) and the Victorian Government's Operational Infrastructure Support Program.