TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea

Holly R Chinnery; Cheng Mee Leong; Weisan Chen; John V Forrester; Paul G McMenamin

Journal article

TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea

Holly R Chinnery, Cheng Mee Leong, Weisan Chen, John V Forrester, Paul G McMenamin

JOURNAL OF LEUKOCYTE BIOLOGY | FEDERATION AMER SOC EXP BIOL | Published : 2015

DOI: 10.1189/jlb.3AB0414-216R

University of Melbourne Researchers

Holly Chinnery Author Optometry and Vision Sciences

Related Projects (1)

Chronic Tlr9 Activation As A Mechanism For Granulomatous Reaction In The Cornea

Corneal opacities due to microbial infections are a major cause of blindness globally. Our novel data show that the presence of viral/bacter..

Grants

Awarded by National Health and Medical Research Council Project Grants Australia

Awarded by Chief Scientist Office

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council Project Grants Australia (#1026301 and #1042612). H.R.C. was supported by a Monash University Faculty Grant Scheme Early Career Research grant. The authors acknowledge the staff at Monash Micro Imaging Facility at Monash University (Victoria, Australia) and the Advanced Microscopy Facility at The Florey for provision of instrumentation, training, and general support. Janet Choi and Jun Shi (University of Melbourne) assisted with animal experiments and ELISA studies.