Improving our resolution of kidney morphogenesis across time and space
Melissa H Little
CURRENT OPINION IN GENETICS & DEVELOPMENT | CURRENT BIOLOGY LTD | Published : 2015
As with many mammalian organs, size and cellular complexity represent considerable challenges to the comprehensive analysis of kidney organogenesis. Traditional analyses in the mouse have revealed early patterning events and spatial cellular relationships. However, an understanding of later events is lacking. The generation of a comprehensive temporospatial atlas of gene expression during kidney development has facilitated advances in lineage definition, as well as selective compartment ablation. Advances in quantitative and dynamic imaging have allowed comprehensive analyses at the level of organ, component tissue and cell across kidney organogenesis. Such approaches will enhance our unders..View full abstract
MHL is an National Health and Medical Research Council (NHMRC) Senior Principal Research Fellow. Her research is supported by the NHMRC, Australian Research Council, Human Frontiers Science Program, Organovo Inc. and the National Institutes of Health (NIDDK), USA. I thank Dr. Alex Combes and Kylie Georgas for assistance with graphics and Associate Professor Jane Black for teaching me about human development.