Journal article

Cytomegalovirus viral load monitoring after allogeneic bone marrow transplantation in patients receiving antiviral prophylaxis

BB Howden, A Michaelides, DW Spelman, A Spencer, AP Schwarer, S Wesselingh, TC Kotsimbos

BONE MARROW TRANSPLANTATION | NATURE PUBLISHING GROUP | Published : 2003

Abstract

Cytomegalovirus viral load measurement is a powerful new tool for monitoring of CMV disease; however, the optimal strategy for use is unknown. Weekly plasma CMV viral loads and CMV-related outcomes were monitored in 46 consecutive allogeneic bone marrow transplantation (BMT) recipients receiving standardised antiviral prophylaxis. A total of 412 CMV viral loads were quantitated in the first 100 days post transplantation with 77 positive samples (19%) in 20 patients (43%). No patient with all negative CMV viral load results developed CMV disease. Two of three patients with highly positive CMV viral loads (first positive or =5000 copies/ml, and > or =50% of samples positive) developed CMV dis..

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University of Melbourne Researchers