Journal article

Effect of CPAP on intrinsic PEEP, inspiratory effort, and lung volume in severe stable COPD

FJ O'Donoghue, PG Catcheside, AS Jordan, AD Bersten, RD McEvoy

THORAX | BRITISH MED JOURNAL PUBL GROUP | Published : 2002

Abstract

BACKGROUND: Intrinsic positive end expiratory pressure (PEEPi) constitutes an inspiratory threshold load on the respiratory muscles, increasing work of breathing. The role of continuous positive airway pressure (CPAP) in alleviating PEEPi in patients with severe stable chronic obstructive pulmonary disease is uncertain. This study examined the effect of CPAP on the inspiratory threshold load, muscle effort, and lung volume in this patient group. METHODS: Nine patients were studied at baseline and with CPAP increasing in increments of 1 cm H(2)O to a maximum of 10 cm H(2)O. Breathing pattern and minute ventilation (I), dynamic PEEPi, expiratory muscle activity, diaphragmatic (PTPdi/min) and o..

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