Journal article

POTENTIAL ANTIINFLAMMATORY EFFECTS OF INTERLEUKIN-4 - SUPPRESSION OF HUMAN MONOCYTE TUMOR NECROSIS FACTOR-ALPHA, INTERLEUKIN-1, AND PROSTAGLANDIN-E2

PH HART, GF VITTI, DR BURGESS, GA WHITTY, DS PICCOLI, JA HAMILTON

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 1989

Abstract

Stimulated human monocytes/macrophages are a source of mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), and prostaglandin E2 (PGE2), which can modulate inflammatory and immune reactions. Therefore, the ability to control the production of such mediators by monocytes/macrophages may have therapeutic benefits, and it has been proposed that glucocorticoids may act in this way. Purified human monocytes, when stimulated in vitro with lipopolysaccharide (LPS) or with LPS and gamma interferon (IFN-gamma), produce TNF-alpha, IL-1, and PGE2. Cotreatment of stimulated cells with the purified human lymphokine, interleukin 4 (IL-4 greater than or equal to 0.1-0.5 unit/ml;..

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