Journal article

HYPOTHESIS - INVITRO EVIDENCE FOR THE INVASIVE AND TUMOR-LIKE PROPERTIES OF THE RHEUMATOID PANNUS

JA HAMILTON

JOURNAL OF RHEUMATOLOGY | J RHEUMATOL PUBL CO | Published : 1983

Abstract

It is often considered that the inflammatory processes in the rheumatoid synovium are due to an immune response to an as yet unknown antigen; the resultant pannus has been referred to as "aggressive, invasive, proliferative and tumor-like." Data are presented which show that arthritogenic group A streptococcal cell walls stimulate human monocyte-macrophages to elevate the plasminogen activator (PA) activity of human synoviocytes. By analogy with other cellular systems, it is suggested that the monocyte-macrophage mediated elevation of synoviocyte PA activity can contribute to the tissue remodelling and cell migration found in the rheumatoid pannus. It is also proposed that the active moiety ..

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