Journal article

The aggregation of early-onset melanoma in young Western Australian families

SV Ward, JG Dowty, RJ Webster, G Cadby, EJ Glasson, JS Heyworth, J Emery, JM Cole, MJ Millward, FM Wood, LJ Palmer



BACKGROUND: Few studies have examined the familial aggregation of melanoma or its co-aggregation with other cancers using whole-population based designs. This study aimed to investigate aggregation patterns in young Western Australian families, using population-based linked health data to identify individuals born in Western Australia between 1974 and 2007, their known relatives, and all incident cancer diagnoses within the resulting 1,506,961 individuals. METHODS: Cox proportional hazards regression models were used to compare the risk of melanoma for first-degree relatives of melanoma cases to that for first-degree relatives of controls, with bootstrapping used to account for correlations ..

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Funding Acknowledgements

The authors wish to acknowledge the Western Australian Data Linkage Branch and the Registrar General of the Western Australian Department of the Attorney General for their assistance and the provision of data. This research was supported by funding from the Australian Government Department of Innovation, Industry, Science and Research (Australian Postgraduate Awards).