Journal article

The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniques

Damjan Vukcevic, John B Carlin, Louise King, Graham L Hall, Anne-Louise Ponsonby, Peter D Sly, Peter Vuillermin, Sarath Ranganathan



There is substantial interest in studying lung function in infants, to better understand the early life origins of chronic lung diseases such as asthma. Multiple breath washout (MBW) is a technique for measuring lung function that has been adapted for use in infants. Respiratory sighs occur frequently in young infants during natural sleep, and in accordance with current MBW guidelines, result in exclusion of data from a substantial proportion of testing cycles. We assessed how sighs during MBW influenced the measurements obtained using data from 767 tests conducted on 246 infants (50% male; mean age 43 days) as part of a large cohort study. Sighs occurred in 119 (15%) tests. Sighs during the..

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Awarded by National Health and Medical Research Council: Centre of Research Excellence

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council: Centre of Research Excellence Grant ID 1035261 (Victorian Centre for Biostatistics; ViCBiostat), Research Fellowship ID 1008396 (Anne-Louise Ponsonby) and Project Grant ID 1009044; and the Shane O'BrienMemorial Asthma Foundation. Research at the Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.