Journal article
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia
M Miyake, K Yamashiro, Y Tabara, K Suda, S Morooka, H Nakanishi, CC Khor, P Chen, F Qiao, I Nakata, Y Akagi-Kurashige, N Gotoh, A Tsujikawa, A Meguro, S Kusuhara, O Polasek, C Hayward, AF Wright, H Campbell, AJ Richardson Show all
Nature Communications | Published : 2015
DOI: 10.1038/ncomms7689
Abstract
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta =3.9 × 10-13) and corneal curvature (Pmeta =2.9 × 10-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta =1.13, Pmeta =0.011). We also find in a mouse model of myopia downregulation of W..
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Awarded by Eye Bank Association of America
Funding Acknowledgements
We thank Ms Kaori Misono, Ms Hatsue Hamanaka and Ms Miwa Fukami for their assistance in animal experiments, IHC and genotyping. We also thank Japan Eye Bank Association for its financial support.