Journal article

Gene-environment interaction of reelin and stress in cognitive behaviours in mice: Implications for schizophrenia

Anna Schroeder, Laetitia Buret, Rachel A Hill, Maarten van den Buuse



Cognitive deficits are a particularly debilitating symptom group in schizophrenia. We investigated the effect of a 'two hit' combination of two factors implicated in schizophrenia development, reelin deficiency and stress, on cognitive behaviours in mice. Male and female heterozygous reelin mice (HRM) and wild-type (WT) controls received the stress hormone, corticosterone (CORT), during early adulthood to simulate chronic stress. The Y-maze, novel object recognition task (NORT), social interaction task and prepulse inhibition (PPI) were used to assess short-term spatial memory, visual non-spatial memory, social recognition memory and sensory gating, respectively. Reelin protein expression wa..

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Funding Acknowledgements

This research was undertaken at The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, supported by project grant funding from the NHMRC. AS is in receipt of a Melbourne International Research Scholarship as well as a Melbourne International Fee Remission Scholarship. RH is supported by a NHMRC Career-Development Fellowship and MvdB is supported by a NHMRC Senior Research Fellowship.