Journal article

Gene-environment interaction of reelin and stress in cognitive behaviours in mice: Implications for schizophrenia

Anna Schroeder, Laetitia Buret, Rachel A Hill, Maarten van den Buuse

BEHAVIOURAL BRAIN RESEARCH | ELSEVIER | Published : 2015

Abstract

Cognitive deficits are a particularly debilitating symptom group in schizophrenia. We investigated the effect of a 'two hit' combination of two factors implicated in schizophrenia development, reelin deficiency and stress, on cognitive behaviours in mice. Male and female heterozygous reelin mice (HRM) and wild-type (WT) controls received the stress hormone, corticosterone (CORT), during early adulthood to simulate chronic stress. The Y-maze, novel object recognition task (NORT), social interaction task and prepulse inhibition (PPI) were used to assess short-term spatial memory, visual non-spatial memory, social recognition memory and sensory gating, respectively. Reelin protein expression wa..

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Grants

Funding Acknowledgements

This research was undertaken at The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, supported by project grant funding from the NHMRC. AS is in receipt of a Melbourne International Research Scholarship as well as a Melbourne International Fee Remission Scholarship. RH is supported by a NHMRC Career-Development Fellowship and MvdB is supported by a NHMRC Senior Research Fellowship.