Evaluation of focused multipolar stimulation for cochlear implants in long-term deafened cats
Shefin S George, Andrew K Wise, James B Fallon, Robert K Shepherd
JOURNAL OF NEURAL ENGINEERING | IOP PUBLISHING LTD | Published : 2015
OBJECTIVE: Focused multipolar (FMP) stimulation has been shown to produce restricted neural activation using intracochlear stimulation in animals with a normal population of spiral ganglion neurons (SGNs). However, in a clinical setting, the widespread loss of SGNs and peripheral fibres following deafness is expected to influence the effectiveness of FMP. APPROACH: We compared the efficacy of FMP stimulation to both monopolar (MP) and tripolar (TP) stimulation in long-term deafened cat cochleae (n = 8). Unlike our previous study, these cochleae contained <10% of the normal SGN population adjacent to the electrode array. We also evaluated the effect of electrode position on stimulation modes ..View full abstract
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Awarded by ARC
This study was funded by The Garnett Passe and Rodney Williams Memorial Foundation, the ARC (LP 130 100 220) and the NHMRC. SSG was supported by an Australian Postgraduate Award through the Australian Government and the Bartholomew Reardon PhD Scholarship through the Bionics Institute. The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. We thank Dr Zachary Smith and Dr Christopher Long for experimental protocol contributions, Philipp Senn for multi-channel stimulator engineering and support, Dr Dexter Irvine and Sam Irving for surgical assistance, Helen Feng for electrode manufacture, Nicole Critch for animal care and Dr Sue Pierce for veterinary advice.