Journal article

Generating a self-organizing kidney from pluripotent cells

Melissa H Little, Minoru Takasato

CURRENT OPINION IN ORGAN TRANSPLANTATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

PURPOSE OF REVIEW: Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organization has generated pituitary, optic cup, liver, brain, intestine, stomach and now kidney. Here, we will describe the cell types present within the self-organizing kidney, how these signal to each other to form a kidney organoid and the potential applications of kidney organoids. RECENT FINDINGS: Protocols for the directed differentiation of human pluripotent cells focus on reca..

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