Journal article

Endoplasmic Reticulum Stress Is Increased in Adipose Tissue of Women with Gestational Diabetes

Stella Liong, Martha Lappas

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

Maternal obesity and gestational diabetes mellitus (GDM) are two increasingly common and important obstetric complications that are associated with severe long-term health risks to mothers and babies. IL-1β, which is increased in obese and GDM pregnancies, plays an important role in the pathophysiology of these two pregnancy complications. In non-pregnant tissues, endoplasmic (ER) stress is increased in diabetes and can induce IL-1β via inflammasome activation. The aim of this study was to determine whether ER stress is increased in omental adipose tissue of women with GDM, and if ER stress can also upregulate inflammasome-dependent secretion of IL-1β. ER stress markers IRE1α, GRP78 and XBP-..

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Grants

Awarded by Career Development Fellowship by the National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

Associate Professor Martha Lappas is supported by a Career Development Fellowship by the National Health and Medical Research Council (NHMRC; grant no. 1047025). This work was funded by grants from the Medical Research Foundation for Women and Babies and Diabetes Australia Research Trust (DART). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.