Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae

Yoshiki Yamaryo-Botte; Arek K Rainczuk; David J Lea-Smith; Rajini Brammananth; Phillip L van der Peet; Peter Meikle; Julie E Ralton; Thusita WT Rupasinghe; Spencer J Williams; Ross L Coppel; Paul K Crellin; Malcolm J McConville

Journal article

Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae

Yoshiki Yamaryo-Botte, Arek K Rainczuk, David J Lea-Smith, Rajini Brammananth, Phillip L van der Peet, Peter Meikle, Julie E Ralton, Thusita WT Rupasinghe, Spencer J Williams, Ross L Coppel, Paul K Crellin, Malcolm J McConville

ACS Chemical Biology | AMER CHEMICAL SOC | Published : 2015

DOI: 10.1021/cb5007689

University of Melbourne Researchers

Phillip van der Peet Author Chemistry

Malcolm McConville Author Biochemistry and Molecular Biology

Peter Meikle Author Bio21 Institute

Spencer Williams Author Chemistry

Julie Ralton Author Biochemistry and Molecular Biology

Related Projects (1)

INVESTIGATING THE MECHANISMS OF REGULATION OF MYCOBACTERIAL CELL WALL BIOSYNTHESIS

Tuberculosis (TB) kills around two million people each year while the causative bacterial species, Mycobacterium tuberculosis, infects one-t..

Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Structural and Functional Microbial Genomics

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by the Australian Research Council (ARC) Centre of Excellence in Structural and Functional Microbial Genomics (COE562063), the National Health and Medical Research Council of Australia (Project grant ID1007676). We also acknowledge the ARC for a Discovery Project and Future Fellowship to S.J.W. M.J.M. is an NHMRC Principal Research Fellow.