Possible Involvement of Muscarinic Receptors in Psychiatric Disorders: A Focus on Schizophrenia and Mood Disorders
B Dean, E Scarr
CURRENT MOLECULAR MEDICINE | BENTHAM SCIENCE PUBL LTD | Published : 2015
A considerable body of data supports a role for the central cholinergic system in the aetiologies of schizophrenia and mood disorders. There have been breakthroughs in gaining structural data on muscarinic receptors (CHRMs), understanding their role in CNS functioning and in synthesising drugs that can specifically target each of the 5 CHRMs. This means it is opportune to consider the role of specific CHRMs in the pathophysiologies of schizophrenia and mood disorders. This review will focus on data suggesting changes in levels of CHRM1 and CHRM4 implicate these receptors in the pathophysiology of schizophrenia whereas data suggest a role for CHRM2 in mood disorders. There will be a selected ..View full abstract
Awarded by NHMRC project grants
BD is an NHMRC Senior Research Fellow (APP1002240) and ES is an ARC Future Fellow (FT100100689). This work was supported in part by NHMRC project grants (APP628699, APP1045619, APP1048544) and an enabling grant (282933), the Victorian Government's Operational Infrastructure Support and the Rebecca Cooper Medical Research Foundation.