Journal article

Emotion-Motion Interactions in Conversion Disorder: An fMRI Study

Selma Aybek, Timothy R Nicholson, Owen O'Daly, Fernando Zelaya, Richard A Kanaan, Anthony S David



OBJECTIVES: To evaluate the neural correlates of implicit processing of negative emotions in motor conversion disorder (CD) patients. METHODS: An event related fMRI task was completed by 12 motor CD patients and 14 matched healthy controls using standardised stimuli of faces with fearful and sad emotional expressions in comparison to faces with neutral expressions. Temporal changes in the sensitivity to stimuli were also modelled and tested in the two groups. RESULTS: We found increased amygdala activation to negative emotions in CD compared to healthy controls in region of interest analyses, which persisted over time consistent with previous findings using emotional paradigms. Furthermore d..

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University of Melbourne Researchers


Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

The study was funded by a UK Medical Research Council Milstein Grant. S.A. was supported by the Boursiere d'Excellence grant (University of Geneva). T.R.N. and A.S.D. were supported by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and the Institute of Psychiatry, King's College London. F.Z. received funding support from NIHR and the MRC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.