Journal article

Live-Cell SERS Endoscopy Using Plasmonic Nanowire Waveguides

Gang Lu, Herlinde De Keersmaecker, Liang Su, Bart Kenens, Susana Rocha, Eduard Fron, Chang Chen, Pol Van Dorpe, Hideaki Mizuno, Johan Hofkens, James A Hutchison, Hiroshi Uji-i

Advanced Materials | WILEY-V C H VERLAG GMBH | Published : 2014


Live-cell surface-enhanced Raman spectroscopy (SERS) endoscopy is developed by using plasmonic nanowire waveguides as endoscopic probes. It is demonstrated that the probe insertion does not stress the cell. Opposed to conventional SERS endoscopy, with excitation at the hotspot within the cell, the remote excitation method yields low-background SERS spectra from specific cell compartments with minimal associated photodamage.

University of Melbourne Researchers



Awarded by European Research Council starting grant (PLASMHACAT grant)

Awarded by Research Foundation - Flanders (FWO)

Awarded by KU Leuven Research Fund

Awarded by Belgian Federal Science Policy Office

Funding Acknowledgements

This work was supported by ITN-SUPERIOR (PITN-GA-2009-238177) funding. H. U. acknowledges financial support from the Japan Science and Technology Agency PRESTO program and a European Research Council starting grant (PLASMHACAT grant # 280064). Support from the Research Foundation - Flanders (FWO) (G.0B55.14, G.0259.12, G.0459.10, G.0197.11), the KU Leuven Research Fund (GOA 2011/03, CREA2009, OT/12/059) and funding from the Belgian Federal Science Policy Office (IAP-VI/27) are gratefully acknowledged. G. L. and C. C. acknowledge the Research Foundation - Flanders (FWO, PDO/13).