Journal article

Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes

AB West, A Zimprich, PJ Lockhart, M Farrer, A Singleton, B Holtom, S Lincoln, A Hofer, L Hill, B Muller-Myhsok, ZK Wszolek, J Hardy, T Gasser

EUROPEAN JOURNAL OF HUMAN GENETICS | NATURE PUBLISHING GROUP | Published : 2001

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder with clinical features of bradykinesia, rigidity, resting tremor and postural instability resulting from the deficiency of dopamine in the nigrostriatal system. Previously we mapped a susceptibility gene for an autosomal dominant form of PD to a 10.6 cM region of chromosome 2p (PARK3; OMIM 602404). A common haplotype shared by two North American kindreds (Families B and C) genealogically traced to Southern Denmark and Northern Germany suggested a founder effect. Here we report progress in the refinement of the PARK3 locus and sequence analysis of candidate genes within the region. Members of families B and C were genotyped using..

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