Journal article

CHRONOTROPIC EFFECTS OF ANGIOTENSIN-I, ANGIOTENSIN-II, BRADYKININ AND VASOPRESSIN IN GUINEA-PIG ATRIA

A NAKASHIMA, JA ANGUS, CI JOHNSTON

EUROPEAN JOURNAL OF PHARMACOLOGY | ELSEVIER | Published : 1982

Abstract

Chronotropic responses to angiotensin I and angiotensin II, vasopressin and bradykinin were measured in guinea pig isolated right atria. Angiotensin II (100-30,000 pg/ml) was slightly more potent than angiotensin I and caused a maximum tachycardia of 30-40 b/min; only 20% of the maximum response to (--)-noradrenaline. Propranolol (1 micro M) or reserpine pretreatment (1 mg/kg i.p., 24 h) did not alter the response to angiotensin II or bradykinin. Converting enzyme inhibition by captopril (10 micrograms/ml) did not affect resting rate nor the response to angiotensin II but shifted the location of the angiotensin I curve by 40 fold to the right. Bradykinin (5-500 ng/ml) caused small increases ..

View full abstract

University of Melbourne Researchers