Journal article

TOPICAL USE OF PROSTACYCLIN IN MICROVASCULAR SURGERY

DJM CRABB, M NIALL, KR KNIGHT, JA ANGUS, BM OBRIEN

BRITISH JOURNAL OF PLASTIC SURGERY | CHURCHILL LIVINGSTONE | Published : 1985

Abstract

Prostacyclin was investigated for its ability to overcome surgically induced spasm of the femoral artery and to increase blood flow through the rabbit epigastric free flap. Topical prostacyclin (200 ng/ml) and lignocaine (20 mg/ml or 2%) each produced near-maximal vasodilatation of large conducting vessels. This resulted in a significant increase in blood flow after 5 minutes for each form of topical treatment, compared to a saline control. However the vasodilatation obtained from lignocaine tended to wear off over 30 minutes. Treatment with systemic indomethacin did not prevent surgical spasm nor the action of prostacyclin in relieving it. Topical 6-oxo-prostaglandin F1 alpha, the major bre..

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