Journal article

ALTERED VENOUS RESPONSES TO VASOCONSTRICTOR AGONISTS AND NERVE-STIMULATION IN HUMAN PRIMARY HYPERTENSION

K SUDHIR, JA ANGUS, MD ESLER, GL JENNINGS, GW LAMBERT, PI KORNER

JOURNAL OF HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 1990

Abstract

The reactivity of human veins, biopsied from the forearms of 15 patients with untreated primary hypertension and 14 normotensive subjects, was studied in vitro. Veins of hypertensive patients were less distensible since the slope of their wall tension-circumference relationships was steeper than in normotensive subjects. There was no difference between the groups with regard to their sensitivity (location of the concentration corresponding to 50% of the maximum response) or their normalized maximum contractile force (Fmax/unit radius) in response to potassium or serotonin. However, veins from hypertensive subjects were less sensitive to noradrenaline and the selective alpha 2-adrenoceptor ag..

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