Journal article

RELAXANT EFFECTS OF ATP AND ADENOSINE ON CANINE LARGE AND SMALL CORONARY-ARTERIES INVITRO

TD WHITE, JA ANGUS

European Journal of Pharmacology | ELSEVIER SCIENCE BV | Published : 1987

Abstract

Rings from greyhound large (3-4 mm internal diameter) and small (less than 200 microns internal diameter) coronary arteries were mounted in water-jacketed tissue baths or a Mulvany myograph, respectively. Relaxations to ATP and adenosine were determined in arteries precontracted with the thromboxane A2 mimetic U46619 or with K+. ATP was a much more effective relaxant of large arteries than adenosine. ATP relaxed large coronaries by an endothelium-dependent mechanism whereas relaxations to adenosine were not endothelium-dependent. In contrast, adenosine appeared to be slightly more effective than ATP in relaxing small coronary arteries. Moreover, adenosine was more effective in relaxing K+-co..

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University of Melbourne Researchers