Journal article
RELAXANT EFFECTS OF ATP AND ADENOSINE ON CANINE LARGE AND SMALL CORONARY-ARTERIES INVITRO
TD WHITE, JA ANGUS
EUROPEAN JOURNAL OF PHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 1987
Abstract
Rings from greyhound large (3-4 mm internal diameter) and small (less than 200 microns internal diameter) coronary arteries were mounted in water-jacketed tissue baths or a Mulvany myograph, respectively. Relaxations to ATP and adenosine were determined in arteries precontracted with the thromboxane A2 mimetic U46619 or with K+. ATP was a much more effective relaxant of large arteries than adenosine. ATP relaxed large coronaries by an endothelium-dependent mechanism whereas relaxations to adenosine were not endothelium-dependent. In contrast, adenosine appeared to be slightly more effective than ATP in relaxing small coronary arteries. Moreover, adenosine was more effective in relaxing K+-co..
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