Pharmacologic modification of blood flow in the rabbit microvasculature with prostacyclin and related drugs

Abstract

The rabbit epigastric free flap was used to investigate the effect of prostacyclin and drugs modifying its synthesis in vivo on microvascular blood flow. Prostacyclin and its analogue carbacyclin caused an increase in flow with a maximal twofold increase at approximately 6.5 and 250 ng/ml. respectively, in the flap. Thromboxane synthetase inhibitors such as dacoxibcn hydrochloride. UK-38, 485, 7-1HA, and midaaole (upto 7 × 10−4 in the flap) as well as the prostaglandins 6-oxo-PCF1α and PCE2 (up to 3.7 and 9.2 ng/ml. respectively, in the flap) all failed to modify the control flow rate in the cutaneous microcirculation. It is concluded that the vasodilator properties of prostacyclin and carba..