Journal article

New insights into vascular reactivity: From altered structure to neural control

JA Angus

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | BLACKWELL SCIENCE | Published : 1997

Abstract

1. The present review covers two aspects of the author's research into the pharmacology of vascular reactivity of isolated vessels and in the intact circulation. First, how 'normal' reactivity is altered by injury or disease and, second, how novel drugs have allowed insight into the role of the cotransmitter neuropeptide Y and 'N' type calcium channels in neurotransmitter release. 2. Acute endothelium removal in the femoral artery of the anaesthetized dog confirmed the obligatory role of these cells in the dilatation response to intra-arterial acetylcholine (ACh). After 4 weeks, conduit arteries respond with a thickened neointima following acute endothelial injury but, provided macrophage-de..

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University of Melbourne Researchers